Despite the COVID pandemic, over 50% (210) of the NOSTONE participants were able to complete the study as planned. The remaining approximately 200 participants will complete the study over the next few months. The last study visit is planned for the end of August 2021. With a proportion of study dropouts of less than 5%, the commitment of the participating patients is remarkable and represents a fundamental contribution to the success of the study. The NOSTONE study team is very grateful to all patients for their cooperation and attention.